Fig. 2: The impact of extrinsic factors that perturb intestinal homeostasis.
From: Intestinal stem cells: guardians of homeostasis in health and aging amid environmental challenges
a Summary of how aging alters ISC function, as well as the ISC niche. b Summary of how diet influences ISC function, as well as the ISC niche. The nutritional composition and the relative levels of nutrients in mouse diets significantly change the adaptive responses of the intestinal epithelium.
