Fig. 6: Prmt7-deficient hearts of OVX-induced mice exhibit altered gene expression profiles associated with the JAK/STAT signaling pathway. | Experimental & Molecular Medicine

Fig. 6: Prmt7-deficient hearts of OVX-induced mice exhibit altered gene expression profiles associated with the JAK/STAT signaling pathway.

From: Prmt7 regulates the JAK/STAT/Socs3 signaling pathway in postmenopausal cardiomyopathy

Fig. 6: Prmt7-deficient hearts of OVX-induced mice exhibit altered gene expression profiles associated with the JAK/STAT signaling pathway.The alternative text for this image may have been generated using AI.

a Enrichment map comparing Gene Ontology (GO) terms between WT and cKO mice. The nodes represent gene sets connected by edges, grouped in subclusters, and manually annotated. b Representative GO terms of subclusters related to “response to stress” from panel a. A gene interaction network was constructed from “response to stress” gene sets, with different lines indicating interaction types. a, b Fold change (FC) > 1.3, normalized data (log2) > 1.0 and P value cutoff < 0.1 according to Student’s t test. The genes were initially analyzed using GSEA, followed by enrichment map analysis using Cytoscape. c qRT‒PCR analysis of the expression levels of genes associated with the JAK/STAT signaling pathway in hearts from WT and cKO mice (n = 3). **P < 0.01, ***P < 0.005. The data represent the mean ± SD. d Immunoblot analysis of hearts from WT and cKO mice.

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