Fig. 8: CERK is associated with the severity of liver injury in humans. | Experimental & Molecular Medicine

Fig. 8: CERK is associated with the severity of liver injury in humans.

From: Ceramide kinase-mediated C1P metabolism attenuates acute liver injury by inhibiting the interaction between KEAP1 and NRF2

Fig. 8

a Representative images of mice subjected to HIRI and stained with hematoxylin and eosin (H&E) are shown. Scale bar: 250 μm. b The protein expression levels of CERK, NRF2, and KEAP1 in mice with HIRI were determined (n = 5/group). c The protein expression levels of CERK, NRF2, and KEAP1 in human primary hepatocytes treated with different concentrations of H2O2 for 24 h were determined (n = 3/group). d The protein expressions of NRF2 and KEAP1 were determined in human primary hepatocytes treated with 20 μM C1P or 2 μM NVP-231 for 24 h and exposed to H2O2 (0.4 mM) (n = 3/group). e Representative images of H&E staining from patients with hepatic lacerations are shown. Scale bar: 250 μm. f Representative images of IHC staining for CERK, NRF2, and KEAP1 in patients with hepatic lacerations are shown. Scale bar: 250 μm.

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