Fig. 1: Mbd2 expression is elevated in tumor tissues. | Experimental & Molecular Medicine

Fig. 1: Mbd2 expression is elevated in tumor tissues.

From: Methyl-CpG binding domain protein 2 (Mbd2) drives breast cancer progression through the modulation of epithelial-to-mesenchymal transition

Fig. 1: Mbd2 expression is elevated in tumor tissues.

a Boxplots showing human MBD2 protein levels in different types of cancer tissues and their normal counterparts according to CPTAC datasets. Statistically significant differences are marked by asterisks, and the number of patients in each group is indicated within each box. Higher expression of MBD2 was observed in tissues from patients with different breast cancer subtypes (b) and at different stages (c) of breast cancer. d A representative immunoblot of the mouse Mbd2 protein from lysates obtained from the mammary fat pads (mfp) of 11-week-old female C57BL/6 (Lane 1) and PyMT mice (Lane 2) and mammary tumors from 20-week-old PyMT mice (Lane 3). GAPDH was used as a loading control. The right panel shows normalized densitometric quantification of the total Mbd2 signal (n = 3 mice/group). The results are shown as the means ± SEMs. Statistical significance was determined via quantitative analysis of total Mbd2 protein expression (sum of Mbd2a and Mbd2b) using ANOVA followed by Tukey’s post hoc test. Statistical significance is indicated by an asterisk.

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