Fig. 1: Enzymatic reactions mediated by GPD1 and GPD2.
From: Glycerol 3-phosphate dehydrogenases (1 and 2) in cancer and other diseases
GPD1, located in the cytosol, reduces the glycolytic intermediate dihydroxyacetone phosphate (DHAP) to glycerol 3-phosphate (G3P) using two electrons from NADH, thus generating NAD+. On the outer surface of the IMM, GPD2 oxidizes G3P back to DHAP by reducing FAD to FADH2 (dehydrogenase activity). It also mediates electron transfer from FADH2 to ubiquinone (Q) (oxidoreductase activity). The blue dashed arrows denote the flow of electrons (depicted as a green ball with “e”).
