Fig. 1: Schematic representation of the roles of PLDs in the modulation of cancer-associated signaling pathways. | Experimental & Molecular Medicine

Fig. 1: Schematic representation of the roles of PLDs in the modulation of cancer-associated signaling pathways.

From: PLD1 is a key player in cancer stemness and chemoresistance: Therapeutic targeting of cross-talk between the PI3K/Akt and Wnt/β-catenin pathways

Fig. 1

The activity and expression of PLD are upregulated by various mitogenic and inflammatory pathways, including Wnt/β-catenin, receptor tyrosine kinase (RTK), G-protein coupled receptor (GPCR), IL-1β, and H. pylori infection pathways. PLD1 and PLD2 are transcriptional targets of Wnt/β-catenin. PLD modulates cancer-associated signaling pathways via lipase activity-dependent and lipase activity-independent functions. PLD-generated choline is converted to various metabolites and acts as an endogenous ligand of the signal-1 receptor. LRP low-density lipoprotein receptor-related protein, LPA lysophosphatidic acid, IL-1β interleukin-1β.

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