Fig. 2: CMTM6 knockdown induces global transcriptomic changes in HCT116 CRC cells.
From: CMTM6 mediates the Warburg effect and promotes the liver metastasis of colorectal cancer
a Upper panel, a volcano plot showing 1005 upregulated and 2679 downregulated transcripts after CMTM6 knockdown in HCT116 CRCs. The horizontal line represents P = 0.05. Vertical lines represent a fold change of 1.5. The green and red dots represent downregulated and upregulated genes, respectively. Lower panel, gene set enrichment analysis (GSEA) revealed numerous pathways that were affected by CMTM6 knockdown in HCT116 cells based on NES > 1 and P < 0.05. NES, normalized enrichment score. b Two gene sets whose gene expression was affected by CMTM6 knockdown are shown. Transcript enrichment is shown by an enrichment plot (left panel), and gene expression levels are shown by a heatmap (right panel). The scale bar represents the minimum (blue) to the maximum expression level (red). c mRNA levels of 14 different glucose transporters were analyzed by RNA sequencing. n.s., P > 0.05 by t test, n = 3.
