Fig. 5: Metabolomic subgroups with upregulated pathways and subtype-specific vulnerabilities. | Experimental & Molecular Medicine

Fig. 5: Metabolomic subgroups with upregulated pathways and subtype-specific vulnerabilities.

From: Proteogenomic characterization identifies clinical subgroups in EGFR and ALK wild-type never-smoker lung adenocarcinoma

Fig. 5: Metabolomic subgroups with upregulated pathways and subtype-specific vulnerabilities.

a Signaling pathway diagram of glycolysis, the citric acid cycle, and oxidative phosphorylation showing significantly upregulated expression in the M subgroup. b Boxplots showing a significantly greater dependency on the CDK9 gene observed exclusively within the P subgroup (P = 0.02). c The TRAF2 gene exhibited heightened dependency on the I subgroup (P = 0.04), (d) the GRB2 to A subgroup (P = 0.01), and (e) the ACACA to M subgroup (P = 0.01).

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