Fig. 6: ErbB4 in SST+ neurons is required for the bimodal activity of CeL On/Off cells.
a, b Proportions of On, Off, and nonresponsive cells in naïve control (N = 14 mice, n = 76 units, white background), SPS (N = 8 mice, n = 32 units, gray background), and SSTErbB4-/- (N = 10 mice, n = 38 units, dark gray background) mice in response to the CS (a) and NC (b). The proportions of On, Off, and nonresponsive cells in response to the CS were comparable across all groups (chi-square test, p > 0.05). However, in response to the NC, the proportions were significantly different between the naïve control and SPS groups (chi-square test, *p = 0.0458) and between the naïve control and SSTErbB4-/- groups (chi-square test, *p = 0.0395). c Proportion of On cells responding to the CS, NC, or both in naïve control (n = 28 units), SPS (n = 19 units), and SSTErbB4-/- (n = 19 units) mice. The proportion of On cells was significantly different only between the naïve control and SSTErbB4-/- groups (chi-square test, *p = 0.0449). d Mean z scores of the responsive activity of On cells to the NC and CS in the naïve control (left panel, Mann‒Whitney U-test, *p = 0.0439), SPS (middle panel; Mann‒Whitney U-test, p > 0.05), and SSTErbB4-/- (right panel; Mann‒Whitney U-test, p > 0.05) groups. e Mean z scores of the responsive activity of Off cells to the NC and CS in the naïve control (left panel, Mann‒Whitney U-test, ***p = 0.0003), SPS (middle panel; Mann‒Whitney U-test, p > 0.05), and SSTErbB4-/- (right panel; Mann‒Whitney U-test, p > 0.05) groups. The data were presented as the means ± SEMs. *p < 0.05, **p < 0.01, ***p < 0.001, and ns not significant.
