Fig. 6: Exhausted CD8+ T cells in cycling status in the pro-metastasis environment for ESCC metastasis. | Experimental & Molecular Medicine

Fig. 6: Exhausted CD8+ T cells in cycling status in the pro-metastasis environment for ESCC metastasis.

From: Single-cell RNA sequencing and spatial transcriptomics of esophageal squamous cell carcinoma with lymph node metastases

Fig. 6

a UMAP plots of CD8+ T cells into 6 clusters. b The relative proportion of exhausted CD8+ T cells (TEX) and exhausted CD8+ T cells in cycling status (Cycling-TEX) among esophageal squamous cell carcinoma, adjacent normal tissue, metastatic lymph nodes and non-metastatic lymph nodes. c Violin plot showing the expression levels of key marker genes of each CD8+ T cell subcluster. d Potential trajectory of differentiation from naïve CD8+ T cells (CD8-TN) into exhausted CD8+ T cells in cycling status (Cycling-TEX) inferred by analysis with Monocle 2. e Comparison of exhausted scores of each subcluster of CD8+ T cells. f Violin plots showing key marker genes of exhausted CD8+ T cells. g Bubble plots comparing ligand-receptor signaling pathways of immune cells between normal lymph nodes (left) and metastatic lymph nodes (right) in metastatic ESCC.

Back to article page