Table 2 Summary of the effects of PARP1 on human RecQ proteins in the presence of RecQ-interacting proteins.

From: RECQL4 requires PARP1 for recruitment to DNA damage, and PARG dePARylation facilitates its associated role in end joining

Interacting partners

Strand annealing

Helicase activity

RECQL4

BLM

RECQ5

RECQL4

BLM

RECQ5

PARP1

Greater stimulation (this study)

Minimal inhibition (this study)

Inhibited39

Greater inhibition (this study)

NA (this study)

Greater inhibition39

PAR

NA (this study)

NA (this study)

Greater stimulation39

NA (this study)

NA (this study)

Inhibited39

  1. RECQL4 and BLM DNA strand annealing and helicase activity were assessed in the presence of PARP1 and PAR. NA not affected.
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