Fig. 1: The dual roles of PGAM5 in the development of inflammation. | Experimental & Molecular Medicine

Fig. 1: The dual roles of PGAM5 in the development of inflammation.

From: The dual role of PGAM5 in inflammation

Fig. 1

PGAM5 predominantly regulates various mitochondrial functions and Nlrp3 inflammasome activation in cells, as well as the activation of innate immune pathways. In addition, PGAM5 is involved in various types of programmed cell death, including apoptosis, necroptosis, pyroptosis and oxeiptosis. In diverse types of inflammation, PGAM5 promotes the secretion of various proinflammatory cytokines to accelerate inflammation. However, it is also an anti-inflammatory agent that can attenuate inflammation and contribute to the maintenance of mitochondrial quantity and quality, thereby maintaining cellular homeostasis in infectious diseases. Even during traumatic brain injury and cellular senescence, PGAM5 has both anti-inflammatory and proinflammatory properties.

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