Fig. 3: PGAM5 can mediate apoptosis and necroptosis.

a The regulation of apoptosis by PGAM5. In unstressed cells, Bcl-xL is unphosphorylated, binds PGAM5 and exerts its anti-apoptotic function. However, Bcl-xL is phosphorylated by PGAM5 to prevent the inhibition of BAX and BAK when cells are exposed to stress, such as chemicals or radiation, ultimately leading to apoptosis. b PGAM5 is a downstream effector of the RIPK1/RIPK3 necroptosome that activates necroptosis through the phosphorylation of CypD and Drp1. Created with BioRender.com.