Table 1 Dual roles of PGAM5 in inflammation.
Effects | Biological processes regulated by PGAM5 | Related inflammatory diseases | Type of cell line | References |
|---|---|---|---|---|
Proinflammatory | Mitochondrial fission, necroptosis | Acute liver injury | Hepatocytes | |
Apoptosis, mitophagy | Hepatic ischemia–reperfusion injury | Hepatocytes | ||
Inflammasome activation | TBI | Microglia | ||
PGAM5–NRF2 axis | Ischemic stroke | Rat brain microvascular endothelial cells (rBMECs) | ||
Apoptosis | AKI | Renal tubular epithelial cells | ||
Necroptosis | Myocardial ischemia–reperfusion injury | Mouse embryonic fibroblasts (MEFs), cardiomyocytes | ||
Mitochondrial fission | Cell senescence | Human retinal epithelial cells | ||
Anti-inflammatory | Mitophagy, mitochondrial biogenesis, pyroptosis | TBI | Neurons | |
Mitochondrial fission | Cellular senescence | Oocytes | ||
TBK1/IRF3-dependent antiviral responses | Vesicular stomatitis virus infection | MEFs | ||
Apoptosis | Myocardial ischemia–reperfusion injury | Cardiomyocytes | ||
Oxeiptosis | Respiratory inflammation caused by viruses | MEFs | ||
Mitophagy | Osteoarthritis | Chondrocytes |
