Table 3 Cell- and organ-specific roles of PGAM5 in inflammation.
Type of inflammation/cell line | Expression of PGAM5 (compared with normal tissues/cells) | Biological processes regulated by PGAM5 | Molecules involved | Signaling pathways involved | References |
|---|---|---|---|---|---|
Hepatic inflammation | High | Mitochondrial fission, necroptosis | Drp1 | cGAS–STING–IRF signaling pathway | |
Hepatic ischemia–reperfusion injury | Unknown | Apoptosis | RNF5, ASK1, miR-330-3p | JNK–p38 signaling pathway | |
TBI | High | Mitophagy, mitochondrial biogenesis, pyroptosis | TFAM, Caspase-1 | NLRP3–Caspase-1–IL-1β signaling pathway | |
Experimental autoimmune encephalomyelitis | High | Necroptosis | Drp1 | – | |
AKI | High | Apoptosis | BAX | cGAS–STING signaling pathway | |
Diabetic tubular injury | High | Mitochondrial fission | Sp1, Drp1 | AMPK–Sp1–PGAM5 pathway | |
Respiratory inflammation caused by viruses | low | Mitochondrial dynamics, oxeiptosis | Mfn2, KEAP1, AIFM1, | RIG-I like receptor signaling pathway | |
Acute lung injury | Unknown | Necroptosis | RIPK3 | – | |
Senescent human retinal epithelial cells | Unknown | Mitochondrial fission | Drp1 | IRF–IFN-β signaling pathway, AMPK–mTOR signaling pathway | |
Senescent oocytes | High | Mitochondrial fission | Drp1 | – |
