Fig. 2: Summary of known consequences of uridine administration in cancer. | Experimental & Molecular Medicine

Fig. 2: Summary of known consequences of uridine administration in cancer.

From: Uridine as a hub in cancer metabolism and RNA biology

Fig. 2: Summary of known consequences of uridine administration in cancer.

Uridine can be imported into cancer cells via CNTs and ENTs to competitively inhibit the incorporation of 5-FU into RNA, minimizing gastrointestinal toxicity while retaining its cytotoxicity to cancer cells. Uridine also has various cytoprotective properties and suppresses oxidative stress and inflammation. ROS, reactive oxygen species. Figure created using Biorender (https://biorender.com/).

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