Fig. 2: Histone lysine lactylation in cancer.
From: Protein lactylation in cancer: mechanisms and potential therapeutic implications
a–d Histone lysine lactylation is related to protumorigenic gene expression (a), lincRNA and circular RNA expression (b) RNA methylation (c) and resistance to cancer therapy (d). e The histone H3 variant CENPA is lactylated to induce HCC proliferation. ABC transporter, ATP-binding cassette transporter; ALKBH3, α-ketoglutarate-dependent dioxygenase AlkB homolog 3; CCN, cyclin; circATXN7, circular RNA ataxin 7; HK1, hexokinase 1; JAK1, janus kinase 1; MDM4, murine double minute 4; METTL3, methyltransferase-like protein 3; NSUN2, NOP2/Sun RNA methyltransferase 2; PER1, period circadian clock 1; SP100A, SP100 nuclear antigen; TP53, tumor protein 53; YTHDF, YTH N6-methyladenosine RNA-binding protein; YY1, ying yang 1.
