Fig. 2: Depletion of vaspin inhibits OA development.
From: Blockade of the vaspin–AP-1 axis inhibits arthritis development
a, Protein expression levels of Mmp3, Mmp13 and Cox2 in IL-1β-treated chondrocytes with or without vaspin knockdown. b, Safranin O staining images (left) and OARSI grading (right) of joint sections from DMM-induced vaspin-KO mice versus control mice (n = 6). c, Left: representative color densitometry 3D micro-CT images of the medial subchondral bone plate thickness (n = 5). Right: the stacked-bar plot uses color to show the trabecular bone thickness distribution in the indicated samples. d, Mechanical allodynia, as measured by the von Frey test (n = 7). The values are presented as the mean ± s.e.m. and were assessed via a one-way ANOVA with Tukey’s multiple-comparisons test (a), the Mann‒Whitney U test (b and d) or two-sided chi-square test (c). **P < 0.01, ***P < 0.001. Scale bar, 100 μm.
