Fig. 1: P. gingivalis infection triggered macrophage infiltration and induced apoptosis and necrosis in periodontal tissues. | Experimental & Molecular Medicine

Fig. 1: P. gingivalis infection triggered macrophage infiltration and induced apoptosis and necrosis in periodontal tissues.

From: Porphyromonas gingivalis induces Zbp1-mediated macrophages PANoptosis in periodonitis pathophysiology

Fig. 1: P. gingivalis infection triggered macrophage infiltration and induced apoptosis and necrosis in periodontal tissues.The alternative text for this image may have been generated using AI.

a t-Distributed Stochastic Neighbor Embedding (t-SNE) plot and stacked bar plots showing cell subtypes of periodontal samples from the single-cell sequencing dataset GSE171213. b Dot plots showing average expression levels (Z-scaled) and percentage of expressed cells (dot size) of marker genes in major cell types. c Cell subtypes of monocyte clusters. d t-SNE plot representing the macrophage clusters of cells identified across healthy and periodontitis. e Increased abundance of macrophage clusters in periodontitis samples. f Elevated proportion of proinflammatory M1 macrophages in periodontitis. g Top 10 bacterial genera in subgingival plaque. h FISH and IF staining showing increased P. gingivalis accumulation and macrophage infiltration in periodontitis tissues. n = 5. Scale bar, 50 μm. i KEGG enrichment analysis revealing abnormal increase in apoptosis and necrosis pathways in periodontitis macrophages. j, k Elevated TUNEL-positive and p-Mlkl+ cells in periodontitis tissues. n = 5. Scale bar, 50 μm. All data were derived from independent experiments. *P < 0.05.

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