Fig. 7: Gliosis and neuroinflammation are induced by transplantation of activated microglia.
From: Microglia-driven inflammation induces progressive tauopathies and synucleinopathies
a Representative IHC images labeled with an antibody specific for Iba1 in the ipsilateral motor cortex 1 month after injection. Scale bar, 50 μm. b–e The relative optical density of Iba1 in the striatum (b), motor cortex (c), hippocampus (d) and rhinal cortex (e) 1, 2 and 4 weeks after injection. All data are presented as the mean ± s.e.m. For statistical analysis, two-way ANOVA followed by Tukey’s post hoc test was performed. f Representative IHC images labeled with an antibody specific for GFAP in the ipsilateral rhinal cortex 1 month after injection. Scale bar, 50 μm. g–j The relative optical density of GFAP in the striatum (g), motor cortex (h), hippocampus (i) and rhinal cortex (j) 1, 2 and 4 weeks after injection. All data are presented as the mean ± s.e.m. For statistical analysis, two-way ANOVA followed by Tukey’s post hoc test was performed. k Representative IHC images labeled with an antibody specific for TNFα in the ipsilateral rhinal cortex 1 month after injection. Scale bar, 100 μm. l–o The relative optical density of TNFα in the striatum (l), motor cortex (m), hippocampus (n) and rhinal cortex (o) 1, 2 and 4 weeks after injection. All data are presented as the mean ± s.e.m. For statistical analysis, two-way ANOVA followed by Tukey’s post hoc test was performed.
