Fig. 7: Single or double knockout of GAS5 and SMARCA4 oncogenes significantly inhibit tumorigenesis in liver cancer models in vivo, as being highly evaluated for therapeutic targets. | Experimental & Molecular Medicine

Fig. 7: Single or double knockout of GAS5 and SMARCA4 oncogenes significantly inhibit tumorigenesis in liver cancer models in vivo, as being highly evaluated for therapeutic targets.

From: Oncogenic function of growth arrest-specific transcript 5 by competing with miR-423-3p to regulate SMARCA4 in hepatocellular carcinoma

Fig. 7

a The liver images were analyzed with Ras-Tg mice at 8 weeks after injection of si-Cont, si-Gas5, si-Smarca4 or si-Gas5 + si-Smarca4 mix in Ras-Tg mouse models. b The graph shows the liver tumor area in each group. c The dot plots show liver weight per body weight ratio in each group. d The liver images were analyzed with Ras-Tg mice at 8 weeks after injection of si-Cont, sorafenib, C12-SPM-siRNA mix or C12-SPM-GAL-siRNA combination in Ras-Tg mouse models. e The graph shows the liver tumor area in each group. f The dot plots show the liver weight per body weight ratio in each group. All the data are shown as the mean ± SEM, *P < 0.05, **P < 0.01; unpaired t-test.

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