Fig. 2: LncRNAs directly bind enzymes to regulate their activity.
From: Long noncoding RNAs regulating enzymatic reactions in cancer
LncRNAs bind to metabolic enzymes and alter their activity. Glycolysis generates pyruvate, which then enters the mitochondrial TCA cycle to produce ATP through oxidative phosphorylation through a series of enzymatic reactions. LncRNAs including WFDC21P, HULC, NEAT1_1, and gLINC can accelerate glucose metabolism through scaffolding and channeling mechanisms. In addition, lncRNAs including TINCR, IDH1-AS1, and AC020978 bind to specific metabolic enzymes in the TCA cycle, enhancing associated metabolic activity. By contrast, lncRNAs such as lncRNA-6195, GAS5, and LOC113230 inhibit the activity of individual metabolic enzymes. Collectively, these findings suggest that lncRNAs impact ATP production, emphasizing their importance in the metabolic reprogramming of cancer.
