Fig. 3: Three distinct conformations of the A62D-8T-bound IR dimer.
From: Structural mechanism of insulin receptor activation by a dimeric aptamer agonist
a–c, Cryo-EM map (a) and structure (b and c) of the IRarrowhead in two different views. The surface representation is shown in c. d–f, Cryo-EM map (d) and structure (e and f) of the IRpseudo-arrowhead in two orientations, shown in the same views as in a–c by aligning the stalk of protomer A to that of IRarrowhead. g–i, Cryo-EM map (g) and structure (h and i) of IRpseudo-gamma in the same views as those of a–c.
