Fig. 4: Structure of the IRpseudo-arrowhead and comparison with other IR structures.
From: Structural mechanism of insulin receptor activation by a dimeric aptamer agonist
a, b The overall structure of the IRpseudo-arrowhead in two views. b is rotated by 180° from (a) about the Y-axis. c Comparison of protomers A and B by aligning the stalks. d Comparison of the two protomers by aligning the L2 domain. e Comparison between the A protomers of IRarrowhead and IRpseudo-arrowhead, aligned by stalks. f Alignment of the A protomers by the L2 domain. g Comparison between the B protomers of IRarrowhead and IRpseudo-arrowhead, aligned by stalks. h Alignment of the B protomers by the L2 domains. IRpseudo-arrowhead and IRarrowhead are shown in orange and blue, respectively.
