Fig. 5: Structure of IRpseudo-gamma and comparison with other IR structures.
From: Structural mechanism of insulin receptor activation by a dimeric aptamer agonist
a, b Two views of IRpseudo-gamma. Protomers A and B are shown in blue and orange, respectively. a, b are related by a 180° rotation about the Y-axis. c Structure of IRgamma in the same orientation as in b, d, Superimposed structures of the A protomers of IRpseudo-gamma (orange), IRpseudo-arrow (blue) and IRarrowhead (gray), aligned by the A62M, showing the relative positions of the FnIII-1 domains between the two protomers. e Comparison of protomer A and B of IRpseudo-gamma by aligning the stalks. IRpseudo-gamma and IRgamma are shown in orange and blue, respectively. f Comparison of protomer A and B of IRpseudo-gamma by aligning the L2 domain. g, h Superimposed structures of the A (g) and B (h) protomers of IRpseudo-gamma and IRgamma, aligned by the FnIII stalks. i, j Superimposed structures of the A (i) and B (j) protomers of IRpseudo-gamma and IRgamma, aligned by the L2 domains.
