Fig. 2: Expression patterns of the CDK1 and β-catenin in human cSCC. | Experimental & Molecular Medicine

Fig. 2: Expression patterns of the CDK1 and β-catenin in human cSCC.

From: Novel small molecules downregulate CDK1 expression and inhibit Wnt/β-catenin signaling in cutaneous squamous cell carcinoma by targeting its distinct tumor-specific cellular landscape

Fig. 2

a, H&E and immunohistochemical staining for Keratin 14 (red) or CDK1 (green) with DAPI nuclear counterstaining (blue) in the human normal skin (n = 3) and cSCC (n = 5) tissues. Dashed lines indicate the boundaries between K14-positive and K14-negative tissues. Scale bar, 100 μm. b, High magnification of CDK1 immunohistochemical staining images with DAPI staining (blue) in the normal skin and cSCC tissues. Scale bar, 100 μm. c, Quantitative analyses of immunohistochemical staining with antibody against CDK1. Three representative fields per patient sample were analyzed. d, Immunohistochemical staining for β-catenin (red), c-Myc (red) and PCNA (green) with DAPI nuclear counterstaining (blue) in the human normal skin (n = 3) and cSCC (n = 5) tissues. Dashed lines represent the border between K14-positive and K14-negative tissues. Scale bar, 100 μm. e, Quantitative analyses of immunohistochemical staining with antibody against β-catenin. Three representative fields per patient sample were analyzed. Data are represented as means ± s.d. ***P < 0.001 for (c and e).

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