Fig. 5: FAIM2 inhibits lipid deposition in hepatocytes. | Experimental & Molecular Medicine

Fig. 5: FAIM2 inhibits lipid deposition in hepatocytes.

From: Fas apoptotic inhibitor molecule 2 mitigates metabolic dysfunction-associated fatty liver disease through autophagic CRTC2 degradation

Fig. 5

a Western blot images of FAIM2 protein expression in hepatocytes from FAIM2 KO and control mice (n = 3). b Nile red-stained images of hepatocytes from the indicated groups treated with PAOA or the bovine serum albumin (BSA) vehicle (n = 3). Scale bar, 25 μm. c Normalized TG content of hepatocytes treated with PAOA or the BSA vehicle in the indicated groups (n = 5). d Normalized mRNA levels of genes related to fatty acid synthesis and inflammation in primary hepatocytes from FAIM2-KO and control mice treated with PAOA (n = 5). e Western blot images of FAIM2 protein expression in hepatocytes infected with AdFaim2 or its control AdGFP (n = 3). f Nile red-stained images of the indicated groups (n = 3). Scale bar, 25 μm. g Normalized TG content of the indicated groups (n = 5). h Normalized mRNA levels of the indicated groups (n = 5). **P < 0.01. The data are expressed as the means ± s.d. Statistical analysis was carried out via one-way ANOVA or two-tailed Student’s t-test.

Back to article page