Fig. 1: HnRNPU is overexpressed in COAD tissues and correlates with poor prognosis. | Experimental & Molecular Medicine

Fig. 1: HnRNPU is overexpressed in COAD tissues and correlates with poor prognosis.

From: RNA-binding protein HnRNPU regulates proliferation and ferroptosis in colon adenocarcinoma by stabilizing the mRNA of system xc−

Fig. 1: HnRNPU is overexpressed in COAD tissues and correlates with poor prognosis.The alternative text for this image may have been generated using AI.

a The expression of HnRNPU mRNA in normal and COAD tissues was analyzed using TIMER 2.0 database. b The mRNA expression levels of HnRNPU in COAD tissues and paired adjacent normal tissues were obtained from the TCGA database. c, d The mRNA expression levels of HnRNPU in normal tissues, colonic polyps tissues, primary colorectal cancer (CRC) tissues and metastatic CRC tissues were analyzed using the GEO databases (GSE68468 and GSE81582). e The HnRNPU protein expression in normal and CRC tissues was analyzed using the CPTAC database. f The protein expression levels of HnRNPU in ten paired samples of COAD tissues and adjacent nontumor tissues were detected using western blot analysis. β-actin was included as an internal control. g A representative image of HnRNPU protein expression in normal and COAD tissues were detected using IHC. Scale bar, 50 μm. h The positive or strong positive rate of HnRNPU protein in COAD and normal colon tissues was analyzed. i Kaplan–Meier analysis curves show the correlation between HnRNPU expression and overall survival rate of patients with COAD. j ROC curves were used to determine the diagnostic value of HnRNPU in COAD using the XIANTAO platform. P value significant codes: *P < 0.05; **P < 0.01; ***P < 0.001.

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