Fig. 6: HnRNPU regulates system xc− -mediated cystine uptake and enhances ferroptosis in COAD. | Experimental & Molecular Medicine

Fig. 6: HnRNPU regulates system xc− -mediated cystine uptake and enhances ferroptosis in COAD.

From: RNA-binding protein HnRNPU regulates proliferation and ferroptosis in colon adenocarcinoma by stabilizing the mRNA of system xc−

Fig. 6: HnRNPU regulates system xc− -mediated cystine uptake and enhances ferroptosis in COAD.The alternative text for this image may have been generated using AI.

a, b Cell viability was determined using CCK-8 in HnRNPU-knockdown SW620 (a) and SW480 (b) cells with or without SLC3A2 or SLC7A11 overexpression. c, d GSH level was detected in HnRNPU-knockdown SW620 (c) and SW480 (d) cells with or without SLC3A2 or SLC7A11 overexpression. e, f Cystine uptake was detected in HnRNPU-knockdown SW620 (e) and SW480 (f) cells with or without SLC3A2 or SLC7A11 overexpression. g, h MDA was detected in HnRNPU-knockdown SW620 (g) and SW480 (h) cells with or without SLC3A2 or SLC7A11 overexpression, under RSL3 treatment. i An electron microscopy technique was applied to determine the changes occurring in the cellular mitochondria in HnRNPU-knockdown cells with or without SLC3A2 or SLC7A11 overexpression with RSL3 treatment. Scale bar, 0.5 μm. P value significant codes: *P < 0.05; **P < 0.01.

Back to article page