Fig. 9: Schematic illustration of HnRNPU-mediated ferroptosis inhibition. | Experimental & Molecular Medicine

Fig. 9: Schematic illustration of HnRNPU-mediated ferroptosis inhibition.

From: RNA-binding protein HnRNPU regulates proliferation and ferroptosis in colon adenocarcinoma by stabilizing the mRNA of system xc−

Fig. 9: Schematic illustration of HnRNPU-mediated ferroptosis inhibition.The alternative text for this image may have been generated using AI.

This model graphically summarizes that HnRNPU binds directly to the 3′ UTRs of SLC7A11 and SLC3A2 mRNAs to enhance their stability, leading to increased expression of these subunits of the cystine/glutamate transporter. This upregulation promotes cystine uptake, suppresses lipid peroxidation and consequently inhibits ferroptosis.

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