Fig. 4: Compound #15 reduces despair-like behavior in animal models of depression. | Experimental & Molecular Medicine

Fig. 4: Compound #15 reduces despair-like behavior in animal models of depression.

From: Exploring neurokinin-1 receptor antagonism for depression with structurally differentiated inhibitors

Fig. 4

Experimental paradigm for LPS model generation and behavioral testing and measurement of despair-like symptoms with or without compound #15 pretreatment. a TST on LPS model; The following groups were included: CON (n = 13), LPS (n = 13), LPS + compound #15 (n = 13) LPS + A (Aprepitant, n = 13). b, c FST on RS (b) and SI (c) model; The following groups were included: CON (n = 19), RS (n = 19), RS + compound #15 (n = 19) in b, and CON (n = 17), SI (n = 17), SI + compound #15 (n = 16) in c. Statistical significance was measured with ANOVA (post-hoc Tukey HSD) and denoted as #P < 0.05, ##P < 0.01, ###P < 0.001, indicating statistical significance compared with the Veh-CON group, and *P < 0.05, **P < 0.01, ***P < 0.001, compared with the Veh-LPS group.

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