Table 1 Murine models for studying lupus myocarditis.
From: Pathogenic drivers of lupus myocarditis and potential therapeutic targets
Mouse strain | Genetic manipulation or pharmacological treatment | Organs undergoing autoimmune inflammation | Identified targets of autoantibodies | Reference |
|---|---|---|---|---|
MRL.lpr | CD274−/− (PD-L1 KO) | Heart and lungs | Cardiac myosin and cardiac troponin I | |
MRL | Pdcd1−/− (PD-1 KO) | Heart, salivary glands, stomach, lungs and liver | Cardiac myosin | |
C57BL/6 | Trex1−/− | Heart, skeletal muscle, tongue, skin, stomach and brain | Cardiac myosin and junctophilin-2 | |
Triple cross between CFN | Resiquimod treatment | Heart | Cardiac myosin and cardiac troponin I | |
B6.Sle1.Sle2.Sle3 triple congenic | Resiquimod treatment | Heart | dsDNA, β2GPI and cardiolipin | |
NZM2410 | – | Heart and kidneys | – |
