Fig. 8: Schematic diagram illustrating MBD2’s role as a methylation reader that inhibits ferroptosis in chondrocytes by enhancing Steap3 promoter methylation. | Experimental & Molecular Medicine

Fig. 8: Schematic diagram illustrating MBD2’s role as a methylation reader that inhibits ferroptosis in chondrocytes by enhancing Steap3 promoter methylation.

From: Methyl-CpG-binding domain 2 mitigates osteoarthritis through Steap3 promoter methylation and chondrocyte ferroptosis regulation

Fig. 8: Schematic diagram illustrating MBD2’s role as a methylation reader that inhibits ferroptosis in chondrocytes by enhancing Steap3 promoter methylation.

In OA cartilage tissue, the nuclear translocation of MBD2 and its binding to the Steap3 promoter are diminished in chondrocytes, resulting in decreased methylation levels of the Steap3 promoter and consequently increased Steap3 expression. Elevated STEAP3 levels enhance the reduction of ferric iron (Fe3+) to ferrous iron (Fe2+) within endosomes, leading to increased lipid peroxidation in chondrocytes and thereby promoting ferroptosis and exacerbating cartilage degeneration.

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