Fig. 4: Downstream genes of EZH2 and E2F1 are regulated by changes in chromatin accessibility. | Experimental & Molecular Medicine

Fig. 4: Downstream genes of EZH2 and E2F1 are regulated by changes in chromatin accessibility.

From: Noncanonical association of EZH2 with E2F1 promotes tumor proliferation through chromatin remodeling

Fig. 4: Downstream genes of EZH2 and E2F1 are regulated by changes in chromatin accessibility.The alternative text for this image may have been generated using AI.

a GO analysis for biological processes using common target genes of EZH2 and E2F1 (n = 306). b GO analysis for the 187 co-downregulated genes. c Average ChIP-seq profiles of EZH2, E2F1 and H3K27me3 around the TSS regions of the co-downregulated genes. d The effect of shEZH2 or shE2F1 in chromatin accessibility around the TSS regions of the co-downregulated genes. e The transcription levels and chromatin accessibility by shEZH2 and shE2F1 at the CCNB1 and RRM2 locus. shCtrl indicates cells transduced with a control vector.

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