Fig. 2: Microtubule dynamic instability and regulation mediated by MBPs.
From: Roles of cytoskeleton in metastasis: from its mechanism to therapeutic strategies
a Microtubules are composed of α- and β-tubulin heterodimers. GTP-bound heterodimers polymerize to form protofilaments, which then assemble into microtubules. Microtubule dynamic instability refers to the continuous transition between phases of growth and shrinkage. b Various MBPs regulate microtubule polymerization and depolymerization. In the illustration, microtubules are represented by green lines and cargos by blue circles.
