Table 2 Drug delivery system for cytoskeleton-targeting anticancer agents.
From: Roles of cytoskeleton in metastasis: from its mechanism to therapeutic strategies
Drug | Mechanism and features | Clinical progress | Reference |
|---|---|---|---|
Liposome–paclitaxel | Targeted liposome: selectively binds to receptors on cancer cells or specific tissues | Phase 3 | |
TFR-targeting liposome–vincristine | TFR-targeting liposome (stimuli-responsive liposome): drug release by specific stimuli such as pH, temperature, ultrasound or enzymes Vincristine: binds to tubulin and inhibits microtubule formation | Preclinical study | |
PLGA–PEG–paclitaxel | PLGA–PEG copolymer: has great potential in drug delivery systems as a tumor-targeting carrier | Preclinical study | |
Dendrimer–paclitaxel | Dendrimer: type of nanostructured drug carrier | Preclinical study |
