Fig. 2: Hh signaling pathway. | Experimental & Molecular Medicine

Fig. 2: Hh signaling pathway.

From: Anti-aging effect of Hedgehog signaling

Fig. 2

Left: in the canonical pathway, Hh ligand binding to Patched 1 (Ptch1) relieves its inhibition of SMO, leading to the activation of Gli transcription factors and the regulation of target gene expression. Right: in the noncanonical pathway, SMO activates downstream signaling independent of Gli, including the CaMKK2–LKB1–AMPK axis, which modulates metabolic regulators such as mTORC1, HMGCR, ALAS and SREBF1, thereby influencing cellular proliferation, differentiation and longevity.

Back to article page