Fig. 8: PTBP1 and NgR KD demonstrates a more potential benefit for PTSD-like behaviors over PTBP1 KD alone, while also rescuing anxiety in normal PTBP1-KD mice. | Experimental & Molecular Medicine

Fig. 8: PTBP1 and NgR KD demonstrates a more potential benefit for PTSD-like behaviors over PTBP1 KD alone, while also rescuing anxiety in normal PTBP1-KD mice.

From: The therapeutic potential and mechanisms of targeting the PTBP1/Nogo-A/NgR axis in PTSD induced by single prolonged stress in mice

Fig. 8: PTBP1 and NgR KD demonstrates a more potential benefit for PTSD-like behaviors over PTBP1 KD alone, while also rescuing anxiety in normal PTBP1-KD mice.

a Total distance in OFT. b Time spent in center zone in the OFT. c Time spent in corner zone in the OFT. d The number of times the central zone was crossed in the OFT. e Time spent in open arm in the EPM. f The number of entries into the open arm in the EPM. g Time spent in closed arm in the EPM. h Anxiety index in the EPM. i Time spent in the target quadrant in the MWM. j The number of crossing platforms in the MWM. k Escape latency in the MWM. Data are expressed as mean ± s.e.m. (n = 11–13), *P < 0.05, **P < 0.01, ***P < 0.001. ****P < 0.0001; ns, not significant.

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