Table 1 Characterization of the hIEC and Caco-2 intestinal epithelial models.

From: Drug-induced gastrointestinal toxicity and barrier integrity: cytoskeleton-mediated impairment in a clinically relevant human intestinal epithelium model

Model

Mean TEER (Ω·cm² ± SEM)*

References TEER (Ω·cm²)

Barrier integrity

Origin

Cell composition

hIEC

129.6 ± 40.9

~80–240

Moderate integrity

hPS cell (in vitro)

Enterocyte, Paneth cell, goblet cell, enteroendocrine cell, stem cell

Caco-2

695.7 ± 126.1

~400–1,200

High integrity

Cancer cell line (in vitro)

Enterocyte

hSI

–

~50–100

Moderate integrity

(In vivo)

Enterocyte, Paneth cell, goblet cell, enteroendocrine cell, Tuft cell, stem cell, transit amplifying cell (epithelium)

  1. TEER measurements (current study and reference values), barrier integrity levels, cellular origins and cell compositions are summarized.
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