Table 2 Clinical GI toxicity profiles of the analyzed drugs.

From: Drug-induced gastrointestinal toxicity and barrier integrity: cytoskeleton-mediated impairment in a clinically relevant human intestinal epithelium model

Drug

Severity grade and score

Incidence and score

Total GI toxicity score (grade × incidence)

Clinical toxicity level

Paclitaxel

Grade 2

2

Very common

3

6

Moderate

Docetaxel

Grade 3

3

Very common

3

9

High

Capecitabine

Grade 3

3

Very common

3

9

High

Cyclophosphamide

Grade 2

2

Common

2

4

Moderate

Cisplatin

Grade 1

1

Very common

3

3

Low–moderate

5-FU

Grade 3

3

Very common

3

9

High

Doxorubicin

Grade 2

2

Common

2

4

Moderate

Gefitinib

Grade 2

2

Very common

3

6

Moderate

Crizotinib

Grade 2

2

Very common

3

6

Moderate

Sunitinib

Grade 2

2

Very common

3

6

Moderate

Sorafenib

Grade 2

2

Very common

3

6

Moderate

Lapatinib

Grade 3

3

Very common

3

9

High

Ibuprofen

Grade 1

1

Common

2

2

Low

Diclofenac

Grade ~1–2

1

Common

2

2

Low

Naproxen

Grade ~1–2

1

Common

2

2

Low

Ketoprofen

Grade ~1–2

1

Common

2

2

Low

Ketorolac

Grade 4

4

Uncommon

1

4

Moderate

  1. GI toxicity levels (low, moderate and high) were determined using integrated severity grades and incidence categories, as described in the Methods. Clinical GI toxicity symptoms were based on FDA guidelines, the DrugBank Database, Drugs.com, information from the Mayo Clinic and relevant literature.
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