Fig. 3: IAA level is reduced in patients with CAD. | Experimental & Molecular Medicine

Fig. 3: IAA level is reduced in patients with CAD.

From: Proline/serine-rich coiled-coil 1 alleviates atherosclerosis via remodeling tryptophan metabolism mediated by Akkermansia muciniphila

Fig. 3: IAA level is reduced in patients with CAD.The alternative text for this image may have been generated using AI.

a The plasma IAA levels in patients without (non-CAD) and with CAD determined by ELISA. b,c The relative mRNA levels of CYP1A1 (b) and PSRC1 (c) (to β-actin) in PBMCs isolated from non-CAD and patients with CAD determined using RT–qPCR (n = 26 in in the non-CAD group and n = 77 in the CAD group). d, A rank-based inverse normal transformation of IAA levels and relative mRNA levels of PSRC1 were performed and the correlation between rank-based inverse IAA levels (RINT IAA) and PSRC1 expression (RINT PSRC1) was analyzed in non-CAD and patients with CAD (n = 103). e Rank-based inverse normal transformation of relative mRNA levels of CYP1A1 were performed and the correlation between rank-based inverse CYP1A1 expression (RINT CYP1A1) and PSRC1 expression (RINT PSRC1) was analyzed in non-CAD and patients with CAD (n = 103). Data are presented as mean ± s.d. Statistical analysis was performed by a Mann–Whitney U test (a–c). Correlation analysis was performed by the partial Pearson test (d and e).

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