Fig. 5: Mcu deficiency disrupts mitochondrial morphology and dynamics during osteoblast differentiation. | Experimental & Molecular Medicine

Fig. 5: Mcu deficiency disrupts mitochondrial morphology and dynamics during osteoblast differentiation.

From: Mcu regulates bone formation via mitochondrial calcium uptake and lineage allocation

Fig. 5: Mcu deficiency disrupts mitochondrial morphology and dynamics during osteoblast differentiation.The alternative text for this image may have been generated using AI.

a Transmission electron microscopy (TEM) images of BMCs and pObs from Mcu WT and iKO mice. Mitochondria are outlined with white; nuclei (N) are labeled in yellow. Black boxes indicate regions that are enlarged and shown on the right. b Quantification of mitochondrial area and length in TEM images. c, d Immunoblot of mitochondrial dynamics regulators in pObs (c) and femoral bone tissues (d). e qPCR of mitochondrial DNA copy number in femoral samples. Data are presented as mean ± s.e.m. Statistical significance: *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001.

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