Fig. 1: Conceptual framework linking organelle-specific zinc dysregulation to disease.
From: Zinc as a master regulator of intracellular organelle homeostasis
Disturbances in intracellular zinc handling lead to zinc imbalance, triggering core molecular dysfunctions that converge on compartment-specific organelle stress responses. Persistent organelle stress contributes to diverse disease phenotypes. By organizing these events into a causal cascade, the framework highlights mechanistic nodes with potential relevance for future organelle-targeted therapeutic modulation.
