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Plasma cell myeloma: multiple calvarial lytic lesions of an individual from the Middle Ages, Poland
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  • Published: 10 May 2026

Plasma cell myeloma: multiple calvarial lytic lesions of an individual from the Middle Ages, Poland

  • Dorota Lorkiewicz-Muszyńska1,2,
  • Szymon Rzepczyk1,
  • Marta Andrzejewska3,4,
  • Katarzyna Derwich3,
  • Marcin Krzepkowski5 &
  • …
  • Iwona Sobkowiak-Tabaka6 

npj Heritage Science (2026) Cite this article

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We are providing an unedited version of this manuscript to give early access to its findings. Before final publication, the manuscript will undergo further editing. Please note there may be errors present which affect the content, and all legal disclaimers apply.

Abstract

A partially preserved cranium affected by multiple lytic lesions was discovered accidentally by a farmer during fieldwork in Rgielsko village, Poland. The discovery was reported to the Prosecutor’s office and the police. Macroscopic and microscopic examinations, medical imaging methods, and radiocarbon dating were conducted. The main aim of the study was to diagnose lytic lesions and to study the archaeological context. The biological profile assessment results indicated the cranium belonged to an adult female. Computed tomography, common in clinical practice, enabled the diagnosis of the lesions as Plasma Cell Myeloma (PCM). Radiocarbon dating results showed that the individual dates to the 11th–12th centuries AD. The examined cranium may help expand the limited paleopathological literature on PCM in Poland and contribute to the global number of reported cases. The clinical examinations were limited to medical imaging studies because other diagnostic tests, such as blood/urine and bone marrow analyses, were not possible.

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Acknowledgements

We thank the Prosecutor's Office in Wągrowiec (Poland) for their permission to publish the author’s study results.

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Authors and Affiliations

  1. Department of Forensic Medicine, Poznań University of Medical Sciences, Poznań, Poland

    Dorota Lorkiewicz-Muszyńska & Szymon Rzepczyk

  2. Department of Forensic Medicine, Collegium Medicum, University of Zielona Góra, Zielona Góra, Poland

    Dorota Lorkiewicz-Muszyńska

  3. Department of Pediatric Oncology, Hematology and Transplantology, Institute of Pediatrics, Poznań University of Medical Sciences, Poznań, Poland

    Marta Andrzejewska & Katarzyna Derwich

  4. Doctoral School, Poznań University of Medical Sciences, Poznań, Poland

    Marta Andrzejewska

  5. Regional Museum in Wągrowiec, Wągrowiec, Poland

    Marcin Krzepkowski

  6. Faculty of Archaeology, Adam Mickiewicz University, Poznań, Poland

    Iwona Sobkowiak-Tabaka

Authors
  1. Dorota Lorkiewicz-Muszyńska
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  2. Szymon Rzepczyk
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  3. Marta Andrzejewska
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  4. Katarzyna Derwich
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  5. Marcin Krzepkowski
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  6. Iwona Sobkowiak-Tabaka
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Corresponding author

Correspondence to Dorota Lorkiewicz-Muszyńska.

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Competing interests

The authors declare no competing interests.

Ethical approval and consent to participate

This article does not contain any studies with living human participants. After the submission of our expert opinion, the authors obtained permission from the Prosecutor’s Office in Wągrowiec (Poland) to publish our results. Authors followed guidance for the ethical treatment of human remains following BABAO (https://www.babao.org.uk/assets/Uploa ds/BABAO‑ Code‑ of‑ Ethics‑ 2019.pdf).

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Cite this article

Lorkiewicz-Muszyńska, D., Rzepczyk, S., Andrzejewska, M. et al. Plasma cell myeloma: multiple calvarial lytic lesions of an individual from the Middle Ages, Poland. npj Herit. Sci. (2026). https://doi.org/10.1038/s40494-026-02613-5

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  • Received: 29 December 2025

  • Accepted: 26 April 2026

  • Published: 10 May 2026

  • DOI: https://doi.org/10.1038/s40494-026-02613-5

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