Table 3 Associations of BMI at age 43 and fat mass index at age 60–64 with Pittsburgh Physical Fatigability Scale (PFS) scores at age 68

From: Are BMI and inflammatory markers independently associated with physical fatigability in old age?

Difference in mean PFS score at age 68 (95% CI)

Model:

Adjustments:

1

Sex

2

1+other main explanatory factors

3

2+covariates

4

3+fatigue at 43

BMI at age 43 (N = 1502)

 Underweight

0.91 (−1.15, 2.97)

0.93 (−1.10, 2.96)

0.66 (−1.27, 2.59)

0.41 (−1.50, 2.31)

 Normal weight

0

0

0

0

 Overweight

0.23 (−0.78, 1.23)

−0.40 (−1.41, 0.60)

−0.77 (−1.72, 0.19)

−0.69 (−1.64, 0.25)

 Obese

4.91 (3.25, 6.58)

3.60 (1.92, 5.27)

2.38 (0.74, 4.02)

2.51 (0.89, 4.13)

Fat mass index at age 60–64 (N = 1189)

Per 1 kg/m2

0.77 (0.61, 0.94)

0.65 (0.47, 0.84)

0.46 (0.29, 0.64)

0.46 (0.28, 0.63)

  1. Model adjustments:
  2. 1: Sex (likelihood ratio tests of sex interaction: BMI p = 0.05, fat mass index p = 0.93; quadratic terms: BMI p = 0.001, fat mass index p = 0.32)
  3. 2: Sex, IL-6 and CRP
  4. 3: Model 2 plus behavioural risk factors (leisure time physical activity and smoking status); health status (symptoms of anxiety and depression, type II diabetes, cardiovascular disease, respiratory symptoms, medication use) and; indicators of socioeconomic position (educational level attained, occupational class)
  5. 4: Model 3 plus fatigue at age 43
  6. Sample restricted to those with complete data on BMI and inflammatory markers at age 60–64 and physical fatigability at age 68 with Ns lower due to missing data on BMI at 43 and fat mass index in the main analytic sample
  7. Analyses run across 20 imputed data sets and results combined using Rubin’s rules. Cut-points for BMI (kg/m2): underweight (<20.0); normal weight (20.0–24.9); overweight (25.0–29.9); obese (≥30.0)
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