Fig. 5

Effect of paternal cholestasis and ursodeoxycholic acid (UDCA) treatment of paternal cholestasis on cardiovascular parameters in the offspring. a Male offspring systolic blood pressure over a 24 h period and mean systolic blood pressure during the light and dark cycles. b Male offspring diastolic blood pressure over a 24 h period and mean diastolic blood pressure during the light and dark cycles. c Male offspring heart rate over a 24 h period and mean heart rate during the light and dark cycles. d Male offspring activity over a 24 h period and mean activity during the light and dark cycles. Data are presented as mean ± SEM; n = 3–4. ^#P ≤ 0.05 for effects due to paternal cholestasis in comparisons vs NC WD; ^†P ≤ 0.05 for effects due to untreated paternal cholestasis in comparisons vs CA+UDCA WD; ^‡for effects due to paternal UDCA treatment in comparisons vs CA WD. Repeated measures two-way ANOVA followed by Tukey's post hoc test was used on 24 h recordings data comparisons, repeated measures one-way ANOVA followed by Newman–Keuls post hoc test was used on mean light and dark cycle comparisons