Table 3 Distribution of allele and genotype frequencies for the three NOS3 polymorphisms

From: Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and metabolic syndrome in healthy subjects and schizophrenia patients

Polymorphism

Genotype/Allele

SCH patients with MetS vs. SCH controls

Patients with MetS vs. healthy controls

SCH patients with MetS (n = 70)

Normal weight SCH patients (n = 190)

OR (95% CI)

P value

MetS patients (n = 155)

Healthy controls (n = 100)

OR (95% CI)

P value

T-786C (rs2070744)

TT

19 (27.1%)

86 (45.3%)

0.45 (0.25–0.82)

0.008

62 (40%)

40 (40%)

1 (0.6–1.67)

1

TC

39 (55.7%)

84 (44.2%)

1.59 (0.91–2.76)

0.099

63 (40.6%)

48 (48%)

0.74 (0.45–1.23)

0.248

CC

12 (17.1%)

20 (10.5%)

1.76 (0.81–3.82)

0.15

30 (19.4%)

12 (12%)

1.76 (0.85–3.63)

0.122

T

77 (55%)

256 (67.4%)

0.59 (0.4–0.88)

0.009

187 (60.3%)

128 (64%)

0.86 (0.59–1.24)

0.404

C

63 (45%)

124 (32.6%)

1.69 (1.14–2.51)

 

123 (39.7%)

72 (36%)

1.17 (0.81–1.69)

G894T (rs1799983)

GG

39 (55.7%)

117 (61.6%)

0.78 (0.45–1.37)

0.392

61 (39.4%)

59 (59%)

0.45 (0.27–0.75)

0.002

GT

27 (38.6%)

60 (31.6%)

1.36 (0.77–2.41)

0.289

75 (48.4%)

35 (35%)

1.74 (1.04–2.92)

0.011

TT

4 (5.7%)

13 (6.8%)

0.83 (0.26–2.62)

0.744

19 (12.3%)

6 (6%)

2.19 (0.84–5.69)

0.0004

G

105 (75%)

294 (77.4%)

0.88 (0.56–1.38)

0.571

197 (63.5%)

153 (76.5%)

0.54 (0.36–0.8)

0.002

T

35 (25%)

86 (22.6%)

1.14 (0.73–1.79)

 

113 (36.5%)

47 (23.5%)

1.87 (1.25–2.79)

C774T (rs1549758)

CC

38 (54.3%)

115 (60.5%)

0.77 (0.45–1.35)

0.364

68 (43.9%)

64 (64%)

0.44 (0.26–0.74)

0.002

CT

26 (37.1%)

60 (31.6%)

1.28 (0.72–2.27)

0.398

73 (47.1%)

31 (31%)

1.98 (1.17–3.36)

0.035

TT

6 (8.6%)

15 (7.9%)

1.09 (0.41–2.94)

0.859

14 (9%)

5 (5%)

1.89 (0.66–5.41)

0.101

C

102 (72.9%)

290 (76.3%)

0.83 (0.54–1.3)

0.417

209 (67.4%)

159 (79.5%)

0.53 (0.35–0.81)

0.003

T

38 (27.1%)

90 (23.7%)

1.2 (0.77–1.87)

 

101 (32.6%)

41 (20.5%)

1.87 (1.23–2.85)

  1. SCH schizophrenia, MetS metabolic syndrome, OR odds ratio, CI confidence interval
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