Table 4 Effects of NOS3 variants on serum biochemical levels in SCH and non-SCH patients with MetS

From: Haplotype analysis of endothelial nitric oxide synthase (NOS3) genetic variants and metabolic syndrome in healthy subjects and schizophrenia patients

Variables

Polymorphism T-786C

Polymorphism G894T

Polymorphism C774T

TT

TC

CC

P value

GG

GT

TT

P value

CC

CT

TT

P value

SCH patients with MetS (n = 70)

Fasting glucose (mmol/l)

5.61 ± 0.77

5.13 ± 0.85

5.15 ± 0.65

0.399

5.78 ± 1.05

5.14 ± 0.44

4.96 ± 0.51

0.12

5.7 ± 0.93

4.95 ± 0.41

5.10 ± 0.57

0.123

Total cholesterol (mmol/l)

4.45 ± 0.97*

5.33 ± 1.25

6.25 ± 0.35

0.046

5.69 ± 1.46

4.99 ± 1.08

5.09 ± 1.32

0.597

5.39 ± 1.23

5.03 ± 1.3

5.09 ± 1.32

0.854

HDL-cholesterol (mmol/l)

1.11 ± 0.34

0.87 ± 0.66

0.92 ± 0.06

0.602

0.86 ± 0.32

0.94 ± 0.42

1.17 ± 0.52

0.536

1 ± 0.41

0.78 ± 0.28

1.17 ± 0.52

0.367

LDL-cholesterol (mmol/l)

3.76 ± 0.97

3.02 ± 0.75

3.6 ± 1.18

0.318

4.15 ± 1.15

3.18 ± 0.61

3.24 ± 1.1

0.166

3.83 ± 0.97

3.12 ± 0.75

3.24 ± 1.1

0.338

Triglycerides (mmol/l)

1.33 ± 0.48

1.55 ± 0.65

1.3 ± 0.44

0.691

1.47 ± 0.68

1.44 ± 0.43

1.24 ± 0.56

0.75

1.4 ± 0.57

1.37 ± 0.57

1.43 ± 0.43

0.986

Nitrites (µmol/l)

32.73 ± 24.18

19.8 ± 17.79

40.16 ± 18.42

0.214

38.43 ± 22

23.73 ± 17.65

29.97 ± 26.23

0.476

39 ± 20.83

28.32 ± 20.42

22.33 ± 22.16

0.439

MetS patients (n = 155)

Fasting glucose (mmol/l)

5.96 ± 0.86

6.27 ± 0.77

6.37 ± 1.11

0.44

6.24 ± 0.92

6.11 ± 0.85

6.16 ± 0.94

0.954

6.27 ± 0.99

6.13 ± 0.7

5.96 ± 1.17

0.766

Total cholesterol (mmol/l)

4.15 ± 1.23

4.4 ± 0.98

4.86 ± 0.33

0.286

4.64 ± 1.11

4.25 ± 0.98

4.21 ± 1.37

0.491

4.71 ± 1.16

4.03 ± 0.82

4.65 ± 1.56

0.12

HDL-cholesterol (mmol/l)

1.19 ± 0.33

1.08 ± 0.23

1.21 ± 0.25

0.386

1.14 ± 0.2

1.19 ± 0.35

1.07 ± 0.21

0.578

1.22 ± 0.27

1.08 ± 0.29

1.15 ± 0.22

0.292

LDL-cholesterol (mmol/l)

2.57 ± 1.16

2.69 ± 0.71

2.89 ± 0.24

0.702

2.93 ± 1

2.47 ± 0.76

2,64 ± 0.98

0.295

2.94 ± 1.05

2.37 ± 0.59

2.95 ± 1.1

0.094

Triglycerides (mmol/l)

1.33 ± 0.63

1.57 ± 0.72

1.38 ± 0.76

0.567

1.52 ± 0.58

1.46 ± 0.79

1.2 ± 0.66

0.536

1.45 ± 0.59

1.44 ± 0.77

1.38 ± 0.8

0.981

Nitrites (µmol/l)

3.94 ± 1.38

4.71 ± 2.54

4.95 ± 1.85

0.402

4.79 ± 1.79

3.67 ± 0.86

4.7 ± 2.57

0.295

4.86 ± 1.87

4.24 ± 2.26

3.95 ± 0.92

0.541

  1. Data are expressed as mean  ±  s.d.
  2. SCH schizophrenia, MetS metabolic syndrome, BMI body mass index, HDL high-density lipoprotein, LDL low-density lipoprotein
  3. *P < 0.05 vs. CC genotype by one-way ANOVA with Fisher’s LSD post hoc test
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