Fig. 1 | International Journal of Obesity

Fig. 1

From: Adipose tissue mitochondrial dysfunction in human obesity is linked to a specific DNA methylation signature in adipose-derived stem cells

Fig. 1

Obesity modifies the hASC methylome. a Schematic representation of the approach performed and the main results obtained (p < 0.0001). b Manhattan plots (−Log10(p) genome-wide association plot). All DMSs achieving the significance threshold are colored in green (p < 0.0001). c Global methylation status of ASCs and mature counterparts. Results are shown as mean ± SEM. t test; *p < 0.05, ***p < 0.001 vs. lean-derived hASCs; ###p < 0.001 vs. obese-derived hASCs. d Supervised cluster analysis and heat map showing the differential groups of CpGs according to their methylation profile in all analyzed samples. n = 6, patients per group. hASCs human adipose-derived stem cells, AD adipocyte, DMS differentially methylated site (color figure online)

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