Table 3 Associations between maternal covariates and umbilical cord SLC6A4CpG5 methylation levels in the SWS cohort

From: Differential SLC6A4 methylation: a predictive epigenetic marker of adiposity from birth to adulthood

Co-variate (continuous)

n

r s

 

p-value

Mother’s pre-preg BMI (kg/m2)

626

−0.028

 

0.48

Pregnancy weight gain (continuous)(kg/week)

593

−0.082

 

0.046*

Co-variate (categorical)

n

Group

Mean methylation (std error)

p-value

Low vitamin D (<50 nmol/L)

230

<50 nmol/L

78.63 (0.38)

0.602

346

≥50 nmol/L

79.19 (0.28)

 

Smoking during pregnancy

544

No

78.84 (0.24)

0.972

85

Yes

79.00 (0.66)

 

Parity

302

0

78.21 (0.36)

0.029*

329

1+

79.47 (0.28)

 

Pregnancy weight gain (categorical)

131

Inadequate

79.78 (4.82)

0.063

186

Adequate

78.75 (5.95)

 

276

Excessive

78.36 (5.87)

 
  1. Association between continuous maternal factors; Mother’s pre-preg BMI and Pregnancy weight gain and SLC6A4 CpG5 methylation using Spearman correlations are shown. Associations between categorical maternal factors: Low vitamin D (<50 nmol/L), Smoking during pregnancy and parity using ranksum test are shown. Associations between categorical maternal factors: Pregnancy weight gain using Kruskal–Wallis test is shown
  2. EP early pregnancy, LP late pregnancy
  3. *p ≤ 0.01–0.05
  4. Bold values indicate a p value lower than 0.05
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